|
| Andhra Pradesh ~ India ~ International ~ City ~ Entertainment ~ Business ~ Bullion ~ Forex ~ Sports ~ Technology ~ Health ~ Features |
| Lung Cancer ~ Lung Cancer ~ Breast Cancer ~ Heart attack ~ All Health Topics |
|
Home
/ Health News / 2008 / August 2008 / August 27, 2008 Sea sponges chemical can trigger cancer cell death |
Barbiturates and narcotics abuse can increase frequency of migraine attacks
A new study has discovered that overusing of certain commonly prescribed medications could increase the frequency of migraine attacks. ANI
Soft-patch device to close hole in heart may prevent recurrent strokes
Scientists at Rush University Medical Center are using a soft-patch device made of a Gore-tex-type material, often used to make durable outerwear, to close a common hole found in the heart called a patent foramen ovale (PFO). ANI
Novel cost-effective screen test can speed up cancer genes discovery
Scientists at Cold Spring Harbor Laboratory (CSHL) have devised a cost-effective screen test that can speed up the rate of discovering cancer-related genes and validating their function in living animals. ANI
Researchers from National Cancer Institute in Frederick have revealed that a natural chemical found in sea sponges can trigger cancer cell death using an unusual pathway.
Washington, Aug 27 : Researchers from National Cancer Institute in Frederick have revealed that a natural chemical found in sea sponges can trigger cancer cell death using an unusual pathway.
The chemical called candidaspongiolide (CAN) stalls protein synthesis and also kills cancer cells by triggering caspase 12-dependent programmed cell death.
Previous studies have shown that CAN preferentially killed glioma and melanoma cells in vitro, but its mechanism was unknown.
In the new study led by Giovanni Melillo, M.D., of the National Cancer Institute in Frederick, Md, the researchers used molecular and cell assays to uncover the mechanism by which CAN kills cancer cells in vitro.
The researchers found that CAN halt protein synthesis in both normal and cancer cells but does not kill normal cells at dosages that trigger cell death in the malignant cells.
The chemical induces cell death by activating caspase 12 by an unusual biochemical pathway.
However, the investigators concluded that further tests with CAN are warranted in vitro and in animal models, which would provide greater insights in its mechanism.
ANI
